Solid State Micro & Nanopore Membranes

High-Precision nanopore Chips for Biosensing, Single-Molecule Detection, and Molecular Diagnostics

The ability to detect and analyze single molecules has transformed modern science and medicine. Since Richard Feynman’s 1959 vision of nanotechnology, researchers have pursued tools that allow them to observe molecular behavior at atomic resolution. Today, nanopore sensing stands at the forefront of this revolution — enabling real-time, label-free, single-molecule analysis with unprecedented sensitivity.

Our solid state micro and nanopore membranes are engineered for precision, scalability, and versatility. Fabricated on materials like Silicon Nitride (SiN), Silicon Dioxide (SiO₂), and Polyimide, we offer pore sizes ranging from 50 nm to 5 µm, with customizable geometries and membrane formats tailored to your research or commercial needs. Each chip is delivered with verified specifications, ensuring consistent performance across applications.

🔍 What Are Nanopores?

Nanopores are ultra-small holes in thin membranes that allow individual biomolecules — such as DNA, RNA, proteins, viruses, and bacteria — to pass through one at a time. As molecules translocate through the pore, they generate measurable signals (typically ionic current fluctuations), enabling researchers to detect, quantify, and characterize them in real time.

Nanopore sensing is:

• 🧪 Label-free – No dyes or amplification steps required
• ⚡ Single-molecule sensitive – Ideal for ultra-low concentration analysis
• 🔬 Real-time – Capture dynamic molecular interactions as they happen

🧠 Why Solid-State Nanopores Matter

Unlike biological nanopores, which are limited by stability and complex embedding processes, solid-state nanopores offer:

• 🧱 Robustness in wet environments
• 🏭 Scalability through semiconductor-grade manufacturing
• 🧩 Integration with electronics, fluidics, and optical systems
• 📐 Dimensional precision for hybrid nanopore applications

Recent advances in materials science have enabled solid-state nanopores to support multiplexed detection, high-throughput analysis, and compatibility with emerging modalities such as:

• 💡 Field-effect transistors (FETs) for low-salt detection and analyte control
• 🔬 Quantum tunneling for molecular fingerprinting
• 🌈 Plasmonic devices for enhanced fluorescence and Raman spectroscopy
• 🤖 Machine learning for signal interpretation and pattern recognition

These innovations are paving the way for next-generation biosensors, diagnostic tools, and molecular screening platforms.

🧫 Product Features

✔️ Custom Pore Sizes – From 50 nm to 5 µm, tailored to your application

✔️ Material Flexibility – SiN, SiO₂, Polyimide, and other thin membranes available

✔️ High Dimensional Accuracy – Verified pore shape and thickness for every chip

✔️ Array Configurations – Single pores or high-density arrays for multiplexed sensing

✔️ Scalable Production – From lab-scale prototypes to industrial volumes

✔️ Specification Sheet Included – Each chip delivered with detailed pore metrics

🔬 Applications of Nanopore Membranes

Our nanopore chips are optimized for a wide range of cutting-edge applications:

🧪 Biosensors & Diagnostics

• Detect viruses, bacteria, and pathogens in clinical samples
• Monitor protein folding, aggregation, and interactions
• Quantify biomarkers in blood, urine, and cerebrospinal fluid

🧬 Genomics & Proteomics

• Sequence DNA and RNA with long-read capability
• Analyze proteoforms and post-translational modifications
• Enable third-generation single-molecule protein sequencing

🧫 Molecular Characterization

• Study particle size, charge, and shape at nanoscale resolution
• Investigate extracellular vesicles, exosomes, and nanoparticles
• Explore gut microbiome and environmental samples

🧠 Emerging Technologies

• DNA memory and molecular computing
• Drug delivery and nanoparticle tracking
• High-throughput screening platforms

🌍 Built for Research, Ready for Innovation

Our membranes are trusted by:

• 🧪 Academic research labs
• 🧬 Biotech and pharma companies
• 🏥 Clinical diagnostics developers
• 🧠 AI-driven biosensor startups
• 🧫 Environmental and food safety researchers

We also offer custom drilling services to fabricate nanopores in any thin membrane material you provide — perfect for experimental setups, novel assays, or proprietary sensor designs.